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藥靶細胞株 > 腫瘤免疫細胞株 > CBP74142Claudin18.2/Miapaca2

Claudin18.2/Miapaca2
名稱 Claudin18.2/Miapaca2
型號 CBP74142
報價
特點 Claudin18.2/Miapaca2
  • 詳細內(nèi)容


CBP74142
I. Background

Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.


II. Introduction

Host Cell:

Miapaca2

Expressed gene:

Claudin18.2

Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:90% FBS+10% DMSO
Culture Medium:

DMEM+10%FBS+5%馬血清+2ug/ml puromycin

Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):Binding Assay,FACS

III. Description of Host Cell Line
Species:Homo sapiens, human
Tissue:pancreas
Disease: carcinoma
Morphology: attached epithelial with floating rounded cells
Growth Mode: attached epithelial with floating rounded cells

IV. Representative Data

1. Claudin18.2/Miapaca2






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